Detectives Jonas and Erik are called to the midnight sun country of northern Norway to investigate a recent homicide, but their plan to arrest the killer goes awry, and Jonas mistakenly shoots Erik. The suspect escapes, and a frightened Jonas pins Erik's death on the fugitive. Jonas continues to pursue the killer as he seeks to protect himself; however, his mounting guilt and the omnipresent sun plague him with an insomnia that affects his sanity.
Ray Breslin manages an elite team of security specialists trained in the art of breaking people out of the world's most impenetrable prisons. When his most trusted operative, Shu Ren, is kidnapped and disappears inside the most elaborate prison ever built, Ray must track him down with the help of some of his former friends.
Leonard Shelby is tracking down the man who raped and murdered his wife. The difficulty of locating his wife's killer, however, is compounded by the fact that he suffers from a rare, untreatable form of short-term memory loss. Although he can recall details of life before his accident, Leonard cannot remember what happened fifteen minutes ago, where he's going, or why.
A burger-loving hit man, his philosophical partner, a drug-addled gangster's moll and a washed-up boxer converge in this sprawling, comedic crime caper. Their adventures unfurl in three stories that ingeniously trip back and forth in time.